職位描述
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崗位職責(zé):
1、負(fù)責(zé)蛋白質(zhì)工程、微生物代謝工程、合成生物學(xué)等項目研發(fā);
2、進(jìn)行項目文獻(xiàn)調(diào)研、實驗計劃的制定、技術(shù)指標(biāo)的實現(xiàn)、項目文檔的撰寫等;
3、配合實驗室日常管理工作,包括實驗室儀器的日常保養(yǎng)和維護(hù)、實驗室菌株資源維護(hù),建立并管理相應(yīng)文檔等;
4、編制并維護(hù)實驗室各類技術(shù)操作規(guī)程,協(xié)助教師對學(xué)生進(jìn)行定期技術(shù)培訓(xùn);
5、完成團(tuán)隊負(fù)責(zé)人安排的其它工作。
崗位要求:
1、生物化學(xué)、生物工程、分子生物學(xué)等相關(guān)專業(yè)碩士畢業(yè),或在相關(guān)專業(yè)本科畢業(yè)后,熟悉枯草芽孢桿菌表達(dá)系統(tǒng),具有1年以上研究經(jīng)歷;
2、具有事業(yè)心,善于開拓進(jìn)取,善于溝通,能吃苦耐勞,具有獨立開展課題的能力,具有強(qiáng)烈的團(tuán)隊協(xié)作精神。
三、待遇
1.固定工資 績效獎勵,具體金額根據(jù)個人情況面議;
2.享受5險1金及學(xué)校規(guī)定的其它待遇。
一、實驗室簡介:
分子酶學(xué)與合成生物學(xué)實驗室依托于上海交通大學(xué)微生物代謝國家重點實驗室,負(fù)責(zé)人是馮雁教授(973項目首席科學(xué)家、生命學(xué)院院長、國家重點實驗室副主任),課題組其它成員包括楊廣宇研究員、崔莉副研究員、張勇副研究員、劉倩副研究員。
實驗室致力于解析微生物關(guān)鍵代謝酶的結(jié)構(gòu)、催化機(jī)制與進(jìn)化規(guī)律,發(fā)展蛋白質(zhì)分子進(jìn)化與合成生物學(xué)技術(shù),針對實際應(yīng)用需求對關(guān)鍵酶進(jìn)行分子設(shè)計與定向進(jìn)化,以期提高酶對非天然底物的選擇性、催化效率及其對環(huán)境的適應(yīng)性等,進(jìn)而構(gòu)建高效、特異的進(jìn)化酶與人工合成途徑。
實驗室承擔(dān)了國家重點研發(fā)計劃,國家自然科學(xué)基金重點項目,國家973計劃項目、863項目、自然科學(xué)基金委重大儀器專項等研究任務(wù)。在Science Adv., Nature Commun., Angew. Chem., JACS, JBC, ACS Synth. Biol., 等著名雜志發(fā)表多篇論文。
近5年代表性論文:
1) Z Li, Y Deng, GY Yang. Growth-coupled high throughput selection for directed enzyme evolution. Biotechnology Advances, 2023, 68, 108238
2) X Jin, GY Yang. Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases. Progress in Lipid Research, 2023, 91, 101241
3) Jingjie Jiang, Guangyu Yang*, Fuqiang Ma*. Fluorescence coupling strategies in fluorescence-activated droplet sorting (FADS) for ultrahigh-throughput screening of enzymes, metabolites, and antibodies. Biotechnol Adv, 2023, 66:108173.
4) B He, X Bai, Y Tan, W Xie, Y Feng, GY Yang. Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products. Synthetic and Systems Biotechnology. 2022, 7 (1), 602-620
5) X Chen, X Jin, F Huang, J Wang, X Cao, PG Wang, Y Feng, F Jiang, GY Yang*. Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety. European Journal of Medicinal Chemistry. 2022, 241, 114636
6) X Bai, D Li, F Ma, X Deng, M Luo, Y Feng, G Yang*. Improved thermostability of creatinase from Alcaligenes Faecalis through non-biased phylogenetic consensus-guided mutagenesis. Microbial cell factories, 2020, 19 (1), 1-13
7) Xi Deng, Liuqing Chen, Mohan Hei, Tiangang Liu, Yan Feng, Guang-Yu Yang*. Structure-guided Reshaping of the Acyl Binding Pocket of 'TesA Thioesterase Enhances Octanoic Acid Production in E. Coli, Metab Eng. 2020, 61:24-32.
8) Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang. Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method. Science Advances, 2019, eaaw8451
9) Fuqiang Ma#, Meng Ting Chung#, Yuan Yao, Robert Nidet, Lap *** Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi*, Guang-Yu Yang*. Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform. Nature Communications, 2018, 9:1030. (#equal contribution)
1、負(fù)責(zé)蛋白質(zhì)工程、微生物代謝工程、合成生物學(xué)等項目研發(fā);
2、進(jìn)行項目文獻(xiàn)調(diào)研、實驗計劃的制定、技術(shù)指標(biāo)的實現(xiàn)、項目文檔的撰寫等;
3、配合實驗室日常管理工作,包括實驗室儀器的日常保養(yǎng)和維護(hù)、實驗室菌株資源維護(hù),建立并管理相應(yīng)文檔等;
4、編制并維護(hù)實驗室各類技術(shù)操作規(guī)程,協(xié)助教師對學(xué)生進(jìn)行定期技術(shù)培訓(xùn);
5、完成團(tuán)隊負(fù)責(zé)人安排的其它工作。
崗位要求:
1、生物化學(xué)、生物工程、分子生物學(xué)等相關(guān)專業(yè)碩士畢業(yè),或在相關(guān)專業(yè)本科畢業(yè)后,熟悉枯草芽孢桿菌表達(dá)系統(tǒng),具有1年以上研究經(jīng)歷;
2、具有事業(yè)心,善于開拓進(jìn)取,善于溝通,能吃苦耐勞,具有獨立開展課題的能力,具有強(qiáng)烈的團(tuán)隊協(xié)作精神。
三、待遇
1.固定工資 績效獎勵,具體金額根據(jù)個人情況面議;
2.享受5險1金及學(xué)校規(guī)定的其它待遇。
一、實驗室簡介:
分子酶學(xué)與合成生物學(xué)實驗室依托于上海交通大學(xué)微生物代謝國家重點實驗室,負(fù)責(zé)人是馮雁教授(973項目首席科學(xué)家、生命學(xué)院院長、國家重點實驗室副主任),課題組其它成員包括楊廣宇研究員、崔莉副研究員、張勇副研究員、劉倩副研究員。
實驗室致力于解析微生物關(guān)鍵代謝酶的結(jié)構(gòu)、催化機(jī)制與進(jìn)化規(guī)律,發(fā)展蛋白質(zhì)分子進(jìn)化與合成生物學(xué)技術(shù),針對實際應(yīng)用需求對關(guān)鍵酶進(jìn)行分子設(shè)計與定向進(jìn)化,以期提高酶對非天然底物的選擇性、催化效率及其對環(huán)境的適應(yīng)性等,進(jìn)而構(gòu)建高效、特異的進(jìn)化酶與人工合成途徑。
實驗室承擔(dān)了國家重點研發(fā)計劃,國家自然科學(xué)基金重點項目,國家973計劃項目、863項目、自然科學(xué)基金委重大儀器專項等研究任務(wù)。在Science Adv., Nature Commun., Angew. Chem., JACS, JBC, ACS Synth. Biol., 等著名雜志發(fā)表多篇論文。
近5年代表性論文:
1) Z Li, Y Deng, GY Yang. Growth-coupled high throughput selection for directed enzyme evolution. Biotechnology Advances, 2023, 68, 108238
2) X Jin, GY Yang. Pathophysiological roles and applications of glycosphingolipids in the diagnosis and treatment of cancer diseases. Progress in Lipid Research, 2023, 91, 101241
3) Jingjie Jiang, Guangyu Yang*, Fuqiang Ma*. Fluorescence coupling strategies in fluorescence-activated droplet sorting (FADS) for ultrahigh-throughput screening of enzymes, metabolites, and antibodies. Biotechnol Adv, 2023, 66:108173.
4) B He, X Bai, Y Tan, W Xie, Y Feng, GY Yang. Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products. Synthetic and Systems Biotechnology. 2022, 7 (1), 602-620
5) X Chen, X Jin, F Huang, J Wang, X Cao, PG Wang, Y Feng, F Jiang, GY Yang*. Design, synthesis and neurite outgrowth activity of novel ganglioside GM1 derivatives by remodeling of the fatty acid moiety. European Journal of Medicinal Chemistry. 2022, 241, 114636
6) X Bai, D Li, F Ma, X Deng, M Luo, Y Feng, G Yang*. Improved thermostability of creatinase from Alcaligenes Faecalis through non-biased phylogenetic consensus-guided mutagenesis. Microbial cell factories, 2020, 19 (1), 1-13
7) Xi Deng, Liuqing Chen, Mohan Hei, Tiangang Liu, Yan Feng, Guang-Yu Yang*. Structure-guided Reshaping of the Acyl Binding Pocket of 'TesA Thioesterase Enhances Octanoic Acid Production in E. Coli, Metab Eng. 2020, 61:24-32.
8) Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang. Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method. Science Advances, 2019, eaaw8451
9) Fuqiang Ma#, Meng Ting Chung#, Yuan Yao, Robert Nidet, Lap *** Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi*, Guang-Yu Yang*. Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform. Nature Communications, 2018, 9:1030. (#equal contribution)
工作地點
地址:商丘梁園區(qū)東川路800號上海交通大學(xué)生命科學(xué)技術(shù)學(xué)院3號樓219室


職位發(fā)布者
瀚海新酶..HR
武漢瀚海新酶生物科技有限公司

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制藥·生物工程
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21-50人
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公司性質(zhì)未知
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東湖新技術(shù)開發(fā)區(qū)高新大道666號光谷生物城c6棟
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